Re: [MLUG - DISCUSSION] Holt-Oram Syndrome

["Jonathan King" <EMAIL:PROTECTED>]

On Wed, Mar 12, 2008 at 11:07 PM, Mike Miller <EMAIL:PROTECTED> wrote:
> On Wed, 12 Mar 2008, Jonathan King wrote:
>
>  > This is conjectured to be an autosomal dominant trait of variable
>  > penetrance. In other words, if one of your parents has it, you are
>  > likely but not certain to have it as well. There is an active discussion
>  > in the literature about whether or not this suggests there is an
>  > interaction between the genotype and some environmental stressor. More
>  > bluntly, maybe you won't get the crooked pinky even if you have the
>  > "bad" gene if the environment is especially conducive to not developing
>  > that abnormality.
>
>  And sometimes the "enviroment" for one gene is the product of another
>  gene.

Obviously. :-) Although people like to distinguish between G x G and G
x E interactions. So people like Terrie Moffitt specialize in finding
the latter while recognizing that the former clearly exist as well.

jking

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