MLUG: Re: [MLUG - DISCUSSION] Holt-Oram Syndrome
Re: [MLUG - DISCUSSION] Holt-Oram Syndrome
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On Wed, 12 Mar 2008, Jonathan King wrote:

This is conjectured to be an autosomal dominant trait of variable penetrance. In other words, if one of your parents has it, you are likely but not certain to have it as well. There is an active discussion in the literature about whether or not this suggests there is an interaction between the genotype and some environmental stressor. More bluntly, maybe you won't get the crooked pinky even if you have the "bad" gene if the environment is especially conducive to not developing that abnormality.

And sometimes the "enviroment" for one gene is the product of another gene.


Mike

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