Re: [MLUG - DISCUSSION] cloning

[Mike Miller <EMAIL:PROTECTED>]

On Thu, 5 Oct 2006, Vern Green wrote:

> Well I know that my sons have the condition with the little finger, and 
> my sister has it, as did my mother.

It is likely autosomal dominant.  That means that 1/2 of your offspring 
will inherit the gene and they would then have a very high chance of 
having the trait.


> Additionally one would have to wonder about Color blindness. I am color 
> blind and the way color blindness works is it skips a generation, but it 
> is hereditary in nature.

X-linked recessive.  That means that you cannot pass it to a son, but you 
can pass the gene to a daughter.  A daughter will not be color blind 
though, usually, because she will have a good copy of the gene from her 
mother.  But the daughter is a carrier, so 1/2 of her sons would be color 
blind.


> I guess what I am asking is if the trait manifested itself with me, 
> would it by nature HAVE to manifest in my clone? This was not something 
> that was externally influenced, but does a trait HAVE to manifest for it 
> to be a full clone?

If the kind of X-linked recessive color blindness that you have has 100% 
penetrance, then your clone will also be colorblind.  If penetrance is 
less than 100% but it is controlled by other loci (genes), then your clone 
will be color blind because you share all those other genes with your 
clone.  If something that controls penetrance (e.g., some environmental 
effect) is not shared with your clone, then the clone might not be color 
blind -- it could be partly a chance outcome.  But with what I know about 
color blindness, I'm going to say that I'm almost certain that your clone 
will be color blind.

Mike

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